Daclatasvir and Lanoxin Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Daclatasvir may increase the blood levels and effects of digoxin. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience nausea, vomiting, diarrhea, loss of appetite, visual disturbances (blurred vision; light halos around objects; green or yellow vision), or an abnormally fast or slow or uneven heartbeat, as these may be signs and symptoms of excessive digoxin levels. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration with daclatasvir may increase the serum concentrations of digoxin. The proposed mechanism is daclatasvir inhibition of the P-glycoprotein-mediated renal tubular secretion of digoxin. When 0.125 mg once daily of digoxin was administered with 60 mg once daily daclatasvir, digoxin peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 65% and 27%, respectively.

MANAGEMENT: Serum digoxin levels and pharmacologic effects should be closely monitored following the addition or withdrawal of daclatasvir, and the digoxin dosage adjusted as needed. Patients already receiving daclatasvir who are initiating digoxin should start at the lowest appropriate digoxin dosage, with further adjustments based on serum digoxin levels and clinical response. Patients already receiving digoxin prior to initiating daclatasvir should have serum digoxin levels taken before starting daclatasvir, then have digoxin levels lowered by reducing dosage approximately 30% to 50% or by modifying the dosing frequency with continued monitoring. Patients should be advised to seek medical attention if they experience signs of digoxin toxicity such as nausea, anorexia, visual disturbances, slow pulse, or irregular heartbeat.

Daclatasvir

Generic Name: daclatasvir

Brand name: Daklinza

Synonyms: n.a.

What is Daclatasvir?

Lanoxin Tablets

Generic Name: digoxin

Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: Digoxin

What is Lanoxin Tablets?