Daclatasvir Dihydrochloride and Noctiva nasal

• Generic Name: daclatasvir
• Dosage Forms: n.a.
• Other Brand Names: Daklinza

Treatment of chronic HCV genotype 1 or genotype 3 infection in treatment-naive (previously untreated) or previously treated adults, including those with cirrhosis (compensated or decompensated), liver transplant recipients, and those with HIV coinfection.

Treatment of chronic HCV genotype 2 or genotype 4 infection; only limited data available.

Must be used in conjunction with other antivirals; do not use alone.

Usually used in a multiple-drug regimen that includes sofosbuvir (with or without ribavirin).

Efficacy of daclatasvir and sofosbuvir (with or without ribavirin) for treatment of HCV genotype 1a infection is reduced in cirrhotic patients with NS5A polymorphisms M28, Q30, L31, or Y93 at baseline. Consider screening for NS5A polymorphisms prior to initiation of treatment in cirrhotic patients with HCV genotype 1a infection. (See General under Dosage and Administration.)

Efficacy of daclatasvir and sofosbuvir (with or without ribavirin) is reduced in cirrhotic patients with HCV genotype 3 infection compared with those without cirrhosis.

Treatment of chronic HCV infection is complex and rapidly evolving; consult a specialist to obtain the most up-to-date information.

• Generic Name: desmopressin
• Dosage Forms: spray, metered
• Other Brand Names: DDAVP nasal, DDAVP Rhinal Tube, Noctiva, Stimate, DDAVP, Nocdurna

Noctiva is a man-made form of a hormone that occurs naturally in the pituitary gland. This hormone affects blood pressure, kidney function, and regulating how the body uses water.

Noctiva is used to treat central cranial diabetes insipidus, and increased thirst and urination caused by head surgery or head trauma.

Stimate is used to treat bleeding episodes in people with hemophilia A or von Willebrand's disease Type I.

Noctiva is used to treat excessive night-time urination in adults who are at least 50 years old. Noctiva should not be used to treat night-time bedwetting.

Noctiva may also be used for purposes not listed in this medication guide.