Daclatasvir Dihydrochloride and Simeprevir

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Simeprevir can increase the blood levels of daclatasvir. This may increase the risk and/or severity of side effects such as headache, fatigue, nausea, and diarrhea. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with simeprevir may increase the plasma concentrations of daclatasvir. The proposed mechanism of interaction is simeprevir inhibition of the intestinal and/or renal efflux of daclatasvir via P-glycoprotein. When daclatasvir 60 mg once daily was administered with simeprevir 150 mg once daily, daclatasvir peak plasma concentration (Cmax), systemic exposure (AUC) and trough plasma concentration (Cmin) increased by 50%, 96% and 168%, respectively. Simeprevir Cmax, AUC and Cmin also increased by 39%, 44% and 49%, respectively, due to inhibition of OATP1B1-mediated hepatic uptake by daclatasvir.

MANAGEMENT: Caution is advised when daclatasvir is used with simeprevir. Patients should be monitored for adverse effects such as headache, fatigue, nausea, diarrhea, and serum lipase elevations.

Daclatasvir Dihydrochloride

Generic Name: daclatasvir

Brand name: Daklinza

Synonyms: Daclatasvir

What is Daclatasvir Dihydrochloride?

Simeprevir

Generic Name: simeprevir

Brand name: Olysio

Synonyms: n.a.

What is Simeprevir?