Daclatasvir Dihydrochloride and Velpatasvir and Sofosbuvir Tablets

• Generic Name: daclatasvir
• Dosage Forms: n.a.
• Other Brand Names: Daklinza

Treatment of chronic HCV genotype 1 or genotype 3 infection in treatment-naive (previously untreated) or previously treated adults, including those with cirrhosis (compensated or decompensated), liver transplant recipients, and those with HIV coinfection.

Treatment of chronic HCV genotype 2 or genotype 4 infection; only limited data available.

Must be used in conjunction with other antivirals; do not use alone.

Usually used in a multiple-drug regimen that includes sofosbuvir (with or without ribavirin).

Efficacy of daclatasvir and sofosbuvir (with or without ribavirin) for treatment of HCV genotype 1a infection is reduced in cirrhotic patients with NS5A polymorphisms M28, Q30, L31, or Y93 at baseline. Consider screening for NS5A polymorphisms prior to initiation of treatment in cirrhotic patients with HCV genotype 1a infection. (See General under Dosage and Administration.)

Efficacy of daclatasvir and sofosbuvir (with or without ribavirin) is reduced in cirrhotic patients with HCV genotype 3 infection compared with those without cirrhosis.

Treatment of chronic HCV infection is complex and rapidly evolving; consult a specialist to obtain the most up-to-date information.

• Generic Name: sofosbuvir / velpatasvir
• Dosage Forms: tablet, film coated
• Other Brand Names: Epclusa

Sofosbuvir and velpatasvir is a combination antiviral medicine used to treat chronic hepatitis C in adults.

sofosbuvir and velpatasvir is sometimes given in combination with another antiviral medicine called ribavirin in people who also have advanced cirrhosis.

Sofosbuvir and velpatasvir treats specific genotypes of hepatitis C, and only in certain people. Use only the medications prescribed for you. Do not share your medicine with other people.

Sofosbuvir and velpatasvir is sometimes used in people who also have HIV. This medicine is not a treatment for HIV or AIDS.

Sofosbuvir and velpatasvir may also be used for purposes not listed in this medication guide.