Daclatasvir Dihydrochloride and Xarelto
Determining the interaction of Daclatasvir Dihydrochloride and Xarelto and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Daclatasvir may increase the blood levels and effects of rivaroxaban. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with daclatasvir may increase the plasma concentrations of drugs that are substrates of the P-glycoprotein (P-gp) transporter. The proposed mechanism is decreased clearance in the intestine, liver, and/or kidney due to inhibition of P-glycoprotein-mediated drug efflux by daclatasvir. When 0.125 mg once daily of digoxin, a P-gp probe substrate, was administered with 60 mg once daily daclatasvir, digoxin peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 65% and 27%, respectively.
MANAGEMENT: Caution is advised when daclatasvir is used concurrently with drugs that are known P-gp substrates, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever daclatasvir is added to or withdrawn from therapy.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Daklinza (daclatasvir)." Bristol-Myers Squibb, Princeton, NJ.
Generic Name: daclatasvir
Brand name: Daklinza
Synonyms: Daclatasvir
Generic Name: rivaroxaban
Brand name: Xarelto, Xarelto Starter Pack
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Daclatasvir Dihydrochloride-Xarelto Starter Pack
- Daclatasvir Dihydrochloride-Xartemis XR
- Daclatasvir Dihydrochloride-Xartemix XR
- Daclatasvir Dihydrochloride-Xatmep
- Daclatasvir Dihydrochloride-Xelitral
- Daclatasvir Dihydrochloride-Xeljanz
- Xarelto-Daclizumab
- Xarelto-Daclizumab Subcutaneous
- Xarelto-Dacogen
- Xarelto-Dacomitinib
- Xarelto-Dactinomycin
- Xarelto-Dactinomycin Injection