Daklinza and Tegretol

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using daclatasvir together with carBAMazepine is not recommended. Combining these medications may significantly decrease the blood levels of daclatasvir, which may reduce its effectiveness in treating hepatitis C. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Coadministration with potent inducers of CYP450 3A4 may significantly decrease the plasma concentration of daclatasvir, which is primarily metabolized by the isoenzyme. When a single 60 mg dose of daclatasvir was administered following pretreatment with the potent CYP450 3A4 inducer rifampin (600 mg once daily), daclatasvir peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 56% and 79%, respectively. Loss of therapeutic efficacy may occur.

MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiviral drug levels, concomitant use of daclatasvir with potent CYP450 3A4 inducers is considered contraindicated.

Daklinza

Generic Name: daclatasvir

Brand name: Daklinza

Synonyms: n.a.

What is Daklinza?

Tegretol

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Tegretol?