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Dalfampridine and InnoPran XL

Determining the interaction of Dalfampridine and InnoPran XL and the possibility of their joint administration.

Check result:

Dalfampridine <> InnoPran XL

Relevance: 19.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Propranolol may increase the blood levels of dalfampridine. You may be more likely to experience side effects such as nausea, insomnia, dizziness, weakness, headache, confusion, and seizures. Contact your doctor if your condition changes or you experience increased side effects during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: The concomitant use of dalfampridine with drugs that are inhibitors of organic cation transporter 2 (OCT2) may theoretically reduce its renal clearance. Dalfampridine is primarily eliminated through renal excretion, approximately 60% of which is via active secretion by OCT2. The risk of CNS excitation and seizures may be increased.

MANAGEMENT: Caution is advised when dalfampridine is used with OCT2 inhibitors.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0
EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid."

Dalfampridine

Generic Name: dalfampridine

Brand name: Ampyra

Synonyms: n.a.

What is Dalfampridine?

InnoPran XL

Generic Name: propranolol

Brand name: Hemangeol, Inderal LA, Inderal XL, InnoPran XL, Inderal, InnoPran XL

Synonyms: n.a.

What is InnoPran XL?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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