Dalfopristin and quinupristin and Neoral

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using dalfopristin together with cycloSPORINE can increase the effects of cycloSPORINE and cause damage to the kidneys or nerve loss. Tell your doctor if you experience dizziness, numbness, skin tingling, muscle twitching, or seizures which may be signs of nerve damage. Talk with your doctor if you develop fever, chills, body aches, flu symptoms, and severe pain in your upper stomach spreading to your back. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Dalfopristin-quinupristin may significantly increase blood concentrations, AUC, and half-life of cyclosporine. The mechanism is inhibition of CYP450 3A4 hepatic metabolism. Cyclosporine-induced neurotoxicity and nephrotoxicity could result.

MANAGEMENT: Cyclosporine levels and renal function, including serum creatinine, should be carefully monitored. Cyclosporine dosage should be adjusted as needed. Patients should be advised to notify their physician if they experience nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, or headache.

Dalfopristin and quinupristin

Generic Name: dalfopristin / quinupristin

Brand name: Synercid

Synonyms: Quinupristin and Dalfopristin

What is Dalfopristin and quinupristin?

Neoral

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Neoral (Capsules, Modified)

What is Neoral?