Danaparoid and Hydrochlorothiazide and amiloride

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using aMILoride together with danaparoid may increase potassium levels in the blood. High levels of potassium can develop into a condition known as hyperkalemia, which in severe cases can lead to kidney failure, muscle paralysis, irregular heart rhythm, and cardiac arrest. You may be more likely to develop hyperkalemia while using these medications if you are elderly, dehydrated, or have kidney disease, diabetes, or advanced heart failure. Regular or long-term use of nonsteroidal anti-inflammatory drugs such as ibuprofen or naproxen (Aleve) may also increase your risk. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat, as these may be symptoms of hyperkalemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: The concomitant use of potassium-sparing diuretics and heparin or low molecular weight heparins may increase the risk of hyperkalemia. Both types of medications have individually been associated with increased potassium levels or hyperkalemia. Patients with renal impairment, diabetes, old age, and severe or worsening heart failure may be at a greater risk.

MANAGEMENT: Caution is advised if potassium-sparing diuretics are used with heparin or low molecular weight heparin. Serum potassium levels and renal function should be checked regularly.

Danaparoid

Generic Name: danaparoid

Brand name:

Synonyms: n.a.

What is Danaparoid?

Hydrochlorothiazide and amiloride

Generic Name: amiloride / hydrochlorothiazide

Brand name: Moduretic 5-50

Synonyms: Amiloride and Hydrochlorothiazide

What is Hydrochlorothiazide and amiloride?