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Danazol and Equetro

Determining the interaction of Danazol and Equetro and the possibility of their joint administration.

Check result:
Danazol <> Equetro
Relevance: 06.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using carBAMazepine together with danazol may increase the effects of carBAMazepine. Contact your doctor if you experience shallow breathing, fast heartbeat, nausea, vomiting, urinating less or not at all, muscle twitches, restlessness, tremors, slurred speech, staggering walk, and feeling light-headed or fainting. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Danazol may increase carbamazepine levels by inhibiting the CYP450 3A4 hepatic metabolism of carbamazepine. Carbamazepine toxicity is possible.

MANAGEMENT: If these drugs must be used together, close observation for clinical and laboratory evidence of carbamazepine toxicity is recommended. Patients should be advised to report possible signs of carbamazepine toxicity (nausea, visual disturbances, dizziness, or ataxia). Dose adjustments may be required.

References
  • Zielinski JJ, Lichten EM, Haidukewych D "Clinically significant danazol-carbamazepine interaction." Ther Drug Monit 9 (1987): 24-7
  • Kramer G, Theisohn M, von Unruh GE, Eichelbaum M "Carbamazepine-danazol drug interaction: its mechanism examined by a stable isotope technique." Ther Drug Monit 8 (1986): 387-92
Danazol

Generic Name: danazol

Brand name: Danocrine

Synonyms: n.a.

Equetro

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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