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Danazol and Gengraf Capsules

Determining the interaction of Danazol and Gengraf Capsules and the possibility of their joint administration.

Check result:

Danazol <> Gengraf Capsules

Relevance: 06.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using cycloSPORINE together with danazol may increase the effects of cycloSPORINE. Contact your doctor if you experience nausea, vomiting, diarrhea, muscle pain or weakness, dizziness, fatigue, or headache. If your doctor prescribes these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Danazol may inhibit the CYP450 3A4 hepatic metabolism of cyclosporine. Trough and steady state levels, and the risk of cyclosporine nephrotoxicity may be increased.

MANAGEMENT: Cyclosporine levels and renal function should be monitored, and dosage should be adjusted as needed and appropriate during therapy. Patients should be advised to notify their physician if they experience nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, or headache.

References

"Product Information. Sandimmune (cyclosporine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
Cockburn IT, Krupp P "An appraisal of drug interactions with sandimmun." Transplant Proc 21 (1989): 3845-50
Ross WB, Roberts D, Griffin PJA, Salaman JR "Cyclosporin interaction with danazol and norethisterone." Lancet 1 (1986): 330
Moller BB, Ekelund B "Toxicity of cyclosporine during treatment with androgens." N Engl J Med 313 (1985): 1416

Danazol

Generic Name: danazol

Brand name: Danocrine

Synonyms: n.a.

What is Danazol?

Gengraf Capsules

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Gengraf (Capsules, Modified), Gengraf

What is Gengraf Capsules?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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