Danocrine and Tacrolimus Granules for Suspension

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using tacrolimus together with danazol may increase the effects of tacrolimus. Contact your doctor if you experience increased side effects such as fever, infection, diarrhea, tremor, headache, fatigue, or lethargy. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Limited data suggest that danazol may inhibit the CYP450 3A4 hepatic metabolism of tacrolimus. Tacrolimus serum concentrations and risk of nephrotoxicity may increase significantly.

MANAGEMENT: Until more data are available, these agents should be used concomitantly only with caution. Close monitoring of tacrolimus concentrations, blood pressure, electrolytes, and kidney function is recommended. Tacrolimus dose reductions may be required. Patients should be advised to report symptoms such as nausea, vomiting, diarrhea, abdominal pain, headache, dizziness, paresthesias, or tremor.

Danocrine

Generic Name: danazol

Brand name: Danocrine

Synonyms: n.a.

What is Danocrine?

Tacrolimus Granules for Suspension

Generic Name: tacrolimus

Brand name: Astagraf XL, Envarsus XR, Prograf, Hecoria

Synonyms: Tacrolimus (oral and injection), Tacrolimus (Systemic)

What is Tacrolimus Granules for Suspension?