Dantrolene Capsules and Verapamil Long-Acting Tablets
Determining the interaction of Dantrolene Capsules and Verapamil Long-Acting Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Talk to your doctor before using verapamil together with dantrolene. Combining these medications may cause high blood potassium levels and irregular heart rhythm. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience nausea, vomiting, dizziness, fatigue, tingling, muscle weakness, slow heartbeat, and/or weak pulse during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Several case reports have suggested that the combination of verapamil and dantrolene may cause hyperkalemia and myocardial depression. The mechanism is unknown. Causality was not definitely established due to the presence of other drugs. Diltiazem may also interact.
MANAGEMENT: The manufacturer recommends that concomitant administration should generally be avoided.
- Cerner Multum, Inc. "Australian Product Information." O 0
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Rubin AS, Zablocki AD "Hyperkalemia, verapamil, and dantrolene." Anesthesiology 66 (1987): 246-9
- Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
- "Product Information. Dantrium (dantrolene)." Procter and Gamble Pharmaceutic, Cincinnati, OH.
Generic Name: dantrolene
Brand name: Dantrium, Dantrium Intravenous, Revonto, Ryanodex
Synonyms: Dantrolene
Generic Name: verapamil
Brand name: Calan, Isoptin SR, Verelan, Isoptin, Calan SR, Isoptin IV, Covera-HS, Verelan PM
Synonyms: Verapamil
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Dantrolene Capsules-Verapamil oral/injection
- Dantrolene Capsules-Verapamil Sustained-Release Capsules
- Dantrolene Capsules-Verdeso
- Dantrolene Capsules-Verdrocet
- Dantrolene Capsules-Verelan
- Dantrolene Capsules-Verelan PM
- Verapamil Long-Acting Tablets-Dantrolene Injection
- Verapamil Long-Acting Tablets-Dantrolene Intravenous
- Verapamil Long-Acting Tablets-Dantrolene Sodium
- Verapamil Long-Acting Tablets-Dapagliflozin
- Verapamil Long-Acting Tablets-Dapagliflozin and metformin
- Verapamil Long-Acting Tablets-Dapagliflozin and Metformin Extended-Release Tablets