Dantrolene Injection and OnabotulinumtoxinA Injection
Determining the interaction of Dantrolene Injection and OnabotulinumtoxinA Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using dantrolene before or after onabotulinumtoxinA may increase the severity of muscle weakness you may experience from treatment with onabotulinumtoxinA. Let your doctor know if you develop excessive muscle weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Excessive muscle weakness associated with the use of botulism toxin may be exaggerated by concomitant use of a skeletal muscle relaxant. Botulinum toxin inhibits the release of acetylcholine from peripheral cholinergic nerve endings and is a neuromuscular blocking agent, thus additive effects may occur with muscle relaxants.
MANAGEMENT: Patients should be advised that muscle weakness may be increased when botulinum toxin is used in combination with skeletal muscle relaxants.
- "Product Information. Dysport (abobotulinumtoxinA)." Tercica Inc, Brisbane, CA.
- "Product Information. Xeomin (botulinum toxin type A (obsolete) (botulinum toxin type A))." Merz Pharmaceuticals, Greensboro, NC.
- "Product Information. Myobloc (botulinum toxin type B)" Elan Pharmaceuticals, S. San Francisco, CA.
- "Product Information. Botox (onabotulinumtoxin A)." Allergan Inc, Irvine, CA.
Generic Name: dantrolene
Brand name: Dantrium, Dantrium Intravenous, Revonto, Ryanodex
Synonyms: Dantrolene
Generic Name: onabotulinumtoxinA
Brand name: Botox, Botox Cosmetic
Synonyms: OnabotulinumtoxinA
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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