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Dantrolene Intravenous and Isoptin SR

Determining the interaction of Dantrolene Intravenous and Isoptin SR and the possibility of their joint administration.

Check result:

Dantrolene Intravenous <> Isoptin SR

Relevance: 02.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using verapamil together with dantrolene. Combining these medications may cause high blood potassium levels and irregular heart rhythm. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience nausea, vomiting, dizziness, fatigue, tingling, muscle weakness, slow heartbeat, and/or weak pulse during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Several case reports have suggested that the combination of verapamil and dantrolene may cause hyperkalemia and myocardial depression. The mechanism is unknown. Causality was not definitely established due to the presence of other drugs. Diltiazem may also interact.

MANAGEMENT: The manufacturer recommends that concomitant administration should generally be avoided.

References

Cerner Multum, Inc. "Australian Product Information." O 0
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Rubin AS, Zablocki AD "Hyperkalemia, verapamil, and dantrolene." Anesthesiology 66 (1987): 246-9
Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
"Product Information. Dantrium (dantrolene)." Procter and Gamble Pharmaceutic, Cincinnati, OH.

Dantrolene Intravenous

Generic Name: dantrolene

Brand name: Dantrium, Dantrium Intravenous, Revonto, Ryanodex

Synonyms: Dantrolene

What is Dantrolene Intravenous?

Isoptin SR

Generic Name: verapamil

Brand name: Calan SR, Isoptin SR, Calan, Verelan, Isoptin, Isoptin IV, Covera-HS, Verelan PM

Synonyms: n.a.

What is Isoptin SR?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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