Dantrolene Sodium and Nia-Chrom

• Generic Name: dantrolene
• Dosage Forms: n.a.
• Other Brand Names: Dantrium, Dantrium Intravenous, Revonto, Ryanodex

Used orally for management of spasticity resulting from upper motor neuron disorders (e.g., multiple sclerosis, cerebral palsy, spinal cord injury, stroke syndrome).

Evidence supporting use is limited and the drug is associated with many adverse effects, some of which may be severe (e.g., hepatotoxicity); however, subtle but meaningful improvement (e.g., decrease in severity of spasticity, ability to resume daily function) may occasionally occur in some patients.

Ineffective in the treatment of amyotrophic lateral sclerosis (ALS).

Not indicated for the treatment of muscle spasms resulting from rheumatic disorders or musculoskeletal trauma.

IV treatment of fulminant hypermetabolism of skeletal muscle that is characteristic of malignant hyperthermia crisis; should be used with and not as a substitute for supportive measures (e.g., oxygen, treatment of metabolic acidosis, cooling procedures).

Dantrolene sodium for injectable suspension (Ryanodex) is designated an orphan drug by FDA for this use.

Also has been used preoperatively to prevent or attenuate the development of malignant hyperthermia in susceptible individuals; however, prophylactic use no longer recommended because of adverse effects and questionable benefit.

Has been used for the treatment of neuroleptic malignant syndrome; fatalities reported despite therapy with the drug.

• Generic Name: chromium picolinate
• Dosage Forms: n.a.
• Other Brand Names: Cr-GTF, CRM, Chromium GTF

Chromium supplements are used to prevent or treat chromium deficiency.

The body needs chromium for normal growth and health. For patients who are unable to get enough chromium in their regular diet or who have a need for more chromium, chromium supplements may be necessary. They are generally taken by mouth but some patients may have to receive them by injection. Chromium helps your body use sugar properly. It is also needed for the breakdown of proteins and fats.

Lack of chromium may lead to nerve problems and may decrease the body's ability to use sugar properly.

There is not enough evidence to show that taking chromium supplements improves the way your body uses sugar (glucose tolerance).

Injectable chromium is given by or under the supervision of a health care professional. Other forms are available without a prescription.