Dantrolene Sodium and RabAvert purified chick embryo cell

• Generic Name: dantrolene
• Dosage Forms: n.a.
• Other Brand Names: Dantrium, Dantrium Intravenous, Revonto, Ryanodex

Used orally for management of spasticity resulting from upper motor neuron disorders (e.g., multiple sclerosis, cerebral palsy, spinal cord injury, stroke syndrome).

Evidence supporting use is limited and the drug is associated with many adverse effects, some of which may be severe (e.g., hepatotoxicity); however, subtle but meaningful improvement (e.g., decrease in severity of spasticity, ability to resume daily function) may occasionally occur in some patients.

Ineffective in the treatment of amyotrophic lateral sclerosis (ALS).

Not indicated for the treatment of muscle spasms resulting from rheumatic disorders or musculoskeletal trauma.

IV treatment of fulminant hypermetabolism of skeletal muscle that is characteristic of malignant hyperthermia crisis; should be used with and not as a substitute for supportive measures (e.g., oxygen, treatment of metabolic acidosis, cooling procedures).

Dantrolene sodium for injectable suspension (Ryanodex) is designated an orphan drug by FDA for this use.

Also has been used preoperatively to prevent or attenuate the development of malignant hyperthermia in susceptible individuals; however, prophylactic use no longer recommended because of adverse effects and questionable benefit.

Has been used for the treatment of neuroleptic malignant syndrome; fatalities reported despite therapy with the drug.

• Generic Name: rabies vaccine, purified chick embryo cell
• Dosage Forms: injection, powder, lyophilized, for suspension
• Other Brand Names: RabAvert

Rabies is a serious disease caused by a virus. Rabies occurs mainly in animals, but a human can get rabies after being bitten by an infected animal. There may be no symptoms at first, but weeks or even months later rabies can cause pain, headaches, tiredness, irritability, fever, hallucinations, seizures, and paralysis. Rabies can be fatal.

You are more likely to be exposed to the rabies virus if you are a veterinarian, animal handler, rabies laboratory worker, or may otherwise come into contact with animals that may carry the virus (including cats, dogs, foxes, skunks, raccoons, bobcats, coyotes, and bats). Traveling to certain countries may also increase your risk of exposure to rabies.

Rabies purified chick embryo cell vaccine is used to protect people who have been bitten by animals (post-exposure) or otherwise may be exposed to the rabies virus (pre-exposure).

This vaccine works by exposing you to a small dose of the virus, which causes the body to develop immunity to the disease. RabAvert is for use in adults and children.

Like any vaccine, the RabAvert may not provide protection from disease in every person.