Dapagliflozin and Larotrectinib Sulfate

• Generic Name: dapagliflozin
• Dosage Forms: n.a.
• Other Brand Names: Farxiga

Dapagliflozin is an oral diabetes medicine that helps control blood sugar levels. Dapagliflozin works by helping the kidneys get rid of glucose from your bloodstream.

Dapagliflozin is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. Dapagliflozin is not for treating type 1 diabetes.

Dapagliflozin may also be used for purposes not listed in this medication guide.

• Generic Name: larotrectinib
• Dosage Forms: n.a.
• Other Brand Names: Vitrakvi

Treatment of solid tumors harboring an NTRK fusion (without a known acquired mutation for resistance) in patients who have metastatic disease or may experience severe morbidity following surgical resection and whose disease progressed following prior therapy or those who are not candidates for other treatment options (designated an orphan drug by FDA for these cancers).

Accelerated approval based on overall response rate and duration of response. Continued approval may be contingent on verification and description of clinical benefit in confirmatory studies.

Confirmation of the presence of NTRK fusion is necessary prior to initiation of therapy. In clinical studies, NTRK fusion status of tumor specimens was determined by fluorescence in situ hybridization (FISH), reverse transcription-polymerase chain reaction (RT-PCR), or next-generation sequencing (NGS).