Dapagliflozin and Metformin Extended-Release Tablets and Nifedical XL
Determining the interaction of Dapagliflozin and Metformin Extended-Release Tablets and Nifedical XL and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using NIFEdipine together with metFORMIN may increase the effects of metFORMIN, which may lead to a life-threatening condition called lactic acidosis This can cause weakness, increasing sleepiness, slow heart rate, muscle pain, shortness of breath, stomach pain, feeling light-headed, and fainting. Talk with your doctor before using NIFEdipine while you are using metFORMIN. You may need a dose adjustment and you may need to check your blood sugar more often. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Nifedipine may increase plasma concentrations of metformin by increasing the extent of absorption. Increased metformin levels may increase the risk of lactic acidosis.
MANAGEMENT: If nifedipine and metformin must be used together, cautious titration of metformin dosage is recommended. Increased metformin levels may increase the risk of lactic acidosis. Patients should be advised to monitor their blood glucose and to promptly notify their physician if they experience possible signs of lactic acidosis such as malaise, myalgia, respiratory distress, hyperventilation, slow or irregular heartbeat, somnolence, abdominal upset, or other unusual symptoms.
- "Product Information. Glucophage (metformin)." Bristol-Myers Squibb, Princeton, NJ.
Generic Name: dapagliflozin / metformin
Brand name: Xigduo XR
Synonyms: Dapagliflozin and metformin, Dapagliflozin and Metformin
Generic Name: nifedipine
Brand name: Adalat CC, Afeditab CR, Nifediac CC, Nifedical XL, Procardia, Procardia XL, Adalat
Synonyms: Nifedical XL (Oral)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Dapagliflozin and Metformin Extended-Release Tablets-Nifedipine
- Dapagliflozin and Metformin Extended-Release Tablets-Nifedipine Capsules
- Dapagliflozin and Metformin Extended-Release Tablets-Nifedipine Extended-Release Tablets
- Dapagliflozin and Metformin Extended-Release Tablets-Niferex
- Dapagliflozin and Metformin Extended-Release Tablets-Niferex Elixir
- Dapagliflozin and Metformin Extended-Release Tablets-Night Cast R Topical
- Nifedical XL-Dapagliflozin and saxagliptin
- Nifedical XL-Dapagliflozin Propanediol
- Nifedical XL-Dapsone
- Nifedical XL-Dapsone (Systemic)
- Nifedical XL-Dapsone Gel
- Nifedical XL-Dapsone topical