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Dapsone and Rifabutin

Determining the interaction of Dapsone and Rifabutin and the possibility of their joint administration.

Check result:

Dapsone <> Rifabutin

Relevance: 13.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Rifabutin may reduce the blood levels and effects of dapsone. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Rifabutin may decrease plasma concentrations of dapsone by inducing its CYP450 3A4 hepatic metabolism. In HIV-infected patients, including rapid and slow acetylators, coadministration of rifabutin (300 mg/day) decreased the AUC of dapsone (50 mg/day) by 27%-40%.

MANAGEMENT: Patients on concomitant therapy should be monitored for inadequate response to dapsone. Dosages should be adjusted as necessary.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0
"Product Information. Mycobutin (rifabutin)." Pharmacia and Upjohn, Kalamazoo, MI.
Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."

Dapsone

Generic Name: dapsone

Brand name:

Synonyms: Dapsone (Systemic)

What is Dapsone?

Rifabutin

Generic Name: rifabutin

Brand name: Mycobutin

Synonyms: n.a.

What is Rifabutin?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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