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Dapsone and Sulfatrim Pediatric

Determining the interaction of Dapsone and Sulfatrim Pediatric and the possibility of their joint administration.

Check result:

Dapsone <> Sulfatrim Pediatric

Relevance: 13.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using dapsone together with trimethoprim may increase the risk and/or severity of side effects such as nausea, vomiting, abdominal pain, liver problems, and impaired bone marrow function resulting in low numbers of different types of blood cells. You may be more likely to develop anemia, bleeding problems, and infections because of low blood cell counts. Of particular concern is the potential development of hemolysis, which is the premature destruction of red blood cells, and methemoglobinemia, a blood disorder that leads to impaired ability of red blood cells to distribute oxygen to tissues. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should seek medical attention if you develop headache, fatigue, dizziness, lightheadedness, fainting, shortness of breath, exercise intolerance, sore throat, fever, unusual bleeding or bruising, and paleness or a bluish discoloration of the skin. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Serum levels of both trimethoprim and dapsone may be increased during coadministration. The mechanism is unknown. Steady state levels are reached within approximately one week.

MANAGEMENT: When these agents are coadministered, monitoring for methemoglobinemia may be important, especially in patients with respiratory insufficiency, anemia, or cardiovascular disease.

References

Lee B, Medina I, Benowitz N, et al "Dapsone, trimethoprim, and sulfamethoxazole plasma levels during treatment of pneumocystis pneumonia in patients with the acquired immunodeficiency syndrome (AIDS)." Ann Intern Med 110 (1989): 606-11
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0
McKinsey D, Durfee D, Kurtin P "Megaloblastic pancytopenia associated with dapsone and trimethorprim treatment of pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome." Arch Intern Med 149 (1989): 965

Dapsone

Generic Name: dapsone

Brand name:

Synonyms: Dapsone (Systemic)

What is Dapsone?

Sulfatrim Pediatric

Generic Name: sulfamethoxazole / trimethoprim

Brand name: Bactrim, Bactrim DS, Bactrim IV, Septra IV, SMZ-TMP DS, Sulfatrim Pediatric, Septra, Sulfatrim, Bethaprim, Cotrim, Uroplus, Uroplus DS, Cotrim DS, Bactrim Pediatric, Bethaprim Pediatric, Sulfatrim Suspension, Cotrim Pediatric, Septra DS

Synonyms: Sulfatrim Pediatric (Oral)

What is Sulfatrim Pediatric?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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