Dapsone Gel and Somatropin, e-coli derived Subcutaneous, Injection
Determining the interaction of Dapsone Gel and Somatropin, e-coli derived Subcutaneous, Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Theoretically, coadministration of dapsone with inducers of CYP450 3A4 such as rifamycins, anticonvulsants, barbiturates, and St. John's wort may increase the formation of dapsone hydroxylamine, a metabolite associated with hemolysis. Dose-related hemolysis is the most common adverse event associated with oral dapsone in both patients with or without glucose-6-phosphate dehydrogenase (G6PD) deficiency. While clinical studies have not demonstrated evidence of clinically significant anemia in patients treated with dapsone 5% gel for acne vulgaris, an increased reticulocyte count and a decreased hemoglobin level were noted to be associated in a G6PD-deficient patient. Exposure to dapsone from the recommended topical dose is about 1% of that from a 100 mg oral dose.
- "Product Information. Aczone (dapsone topical)." QLT USA, Inc, Fort Collins, CO.
Generic Name: dapsone topical
Brand name: Aczone
Synonyms: Dapsone topical, Dapsone (Topical)
Generic Name: somatropin
Brand name: Genotropin, Humatrope, Norditropin FlexPro Pen, Nutropin AQ NuSpin 10, Nutropin AQ Pen 10 Cartridge, Omnitrope, Saizen, Serostim, Zomacton, Zorbtive, Nutropin, Norditropin, Nutropin AQ, Nutropin Depot, Norditropin Cartridge, Genotropin Miniquick, Tev-Tropin, Norditropin Nordiflex Pen, Saizen Click-Easy, Omnitrope Pen 5 Cartridge, HumatroPen, Omnitrope Pen 10 Cartridge, Nutropin AQ Pen 20 Cartridge, Nutropin AQ NuSpin 5, Nutropin AQ NuSpin 20, Saizen Kit
Synonyms: Somatropin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Dapsone Gel-Somatropin, mammalian derived Subcutaneous, Injection
- Dapsone Gel-Somatuline Depot
- Dapsone Gel-Somavert
- Dapsone Gel-Sominex
- Dapsone Gel-Somnote
- Dapsone Gel-Sonahist
- Somatropin, e-coli derived Subcutaneous, Injection-Dapsone topical
- Somatropin, e-coli derived Subcutaneous, Injection-Daptacel
- Somatropin, e-coli derived Subcutaneous, Injection-Daptomycin
- Somatropin, e-coli derived Subcutaneous, Injection-Daptomycin Injection
- Somatropin, e-coli derived Subcutaneous, Injection-Daptomycin Intravenous
- Somatropin, e-coli derived Subcutaneous, Injection-Daranide