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Daraprim and Neut

Determining the interaction of Daraprim and Neut and the possibility of their joint administration.

Check result:

Daraprim <> Neut

Relevance: 04.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using pyrimethamine together with sodium bicarbonate can decrease the effects of pyrimethamine. You should notify your doctor if use pyrimethamine together with sodium bicarbonate. Sodium bicarbonate should be administered at least 2 to 3 hours apart from pyrimethamine. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: The concomitant administration of antacids or absorbent antidiarrheals may significantly reduce the bioavailability of pyrimethamine by reducing its absorption. Therapeutic failure may result.

MANAGEMENT: Antacids and antidiarrheals should be taken at least 2 to 3 hours apart from pyrimethamine.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
"Multum Information Services, Inc. Expert Review Panel"

Daraprim

Generic Name: pyrimethamine

Brand name: Daraprim

Synonyms: n.a.

What is Daraprim?

Neut

Generic Name: sodium bicarbonate

Brand name: Neut

Synonyms: Neut Injection

What is Neut?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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