Darbepoetin alfa Injection and Gengraf Capsules

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Both cycloSPORINE and darbepoetin alfa can increase blood pressure, and the effect may be greater when these medications are combined. In addition, because darbepoetin alfa affects red blood cells, it may alter the blood levels of cycloSPORINE. You may need to have your blood pressure and drug levels checked more frequently by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects of cycloSPORINE. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Concomitant use of cyclosporine with erythropoiesis-stimulating agents (ESAs) may produce additive increases on blood pressure. Either treatment alone may commonly cause hypertension, which can be severe or difficult to control in some cases. Additionally, use of ESAs may alter cyclosporine blood levels, since cyclosporine is bound by red blood cells.

MANAGEMENT: Caution is advised if cyclosporine is prescribed in combination with ESAs. Blood pressure should be adequately controlled before initiating treatment and monitored periodically during treatment. Patients who develop hypertension that is difficult to control by medications or dietary measures should have their ESA treatment reduced or withheld. In addition, cyclosporine blood levels should be checked regularly, as changes may occur following the addition, withdrawal, or change of dosage of ESA therapy. Dosage adjustments for cyclosporine may be required with increases in hematocrit levels.

Darbepoetin alfa Injection

Generic Name: darbepoetin alfa

Brand name: Aranesp, Aranesp SureClick, Aranesp Albumin Free, Aranesp SingleJect

Synonyms: Darbepoetin alfa, Darbepoetin Alfa

What is Darbepoetin alfa Injection?

Gengraf Capsules

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Gengraf (Capsules, Modified), Gengraf

What is Gengraf Capsules?