Darbepoetin alfa Injection and Ofatumumab Intravenous

• Generic Name: darbepoetin alfa
• Dosage Forms: n.a.
• Other Brand Names: Aranesp, Aranesp SureClick, Aranesp Albumin Free, Aranesp SingleJect

Darbepoetin alfa injection causes the bone marrow to produce red blood cells. If the body does not produce enough red blood cells, severe anemia can occur. This often occurs in people with chronic kidney failure whose kidneys are not working properly. Darbepoetin may be used for patients on kidney dialysis or for those not on dialysis. Anemia can also occur in people who are receiving chemotherapy to treat cancer. Darbepoetin alfa is used to treat severe anemia in these patients.

Darbepoetin alfa is available only with your doctor's prescription.

• Generic Name: ofatumumab
• Dosage Forms: n.a.
• Other Brand Names: Arzerra

Ofatumumab injection is used in combination with chlorambucil to treat a type of cancer of the white blood cells called chronic lymphocytic leukemia (CLL) in patients who have not received any treatments in the past. It is also used in combination with fludarabine and cyclophosphamide to treat patients with relapsed CLL. Ofatumumab is also used in patients with CLL who have already been treated with other medicines (eg, alemtuzumab, fludarabine) that did not work well.

Ofatumumab interferes with the growth of cancer cells, which are eventually destroyed by the body. Since the growth of normal body cells may also be affected by ofatumumab, other unwanted effects will also occur. Some of these may be serious and must be reported to your doctor. Some unwanted effects, such as a skin rash, may not be serious but may cause concern. Some of the unwanted effects do not occur until months or years after the medicine is used.

Before you begin treatment with ofatumumab, you and your doctor should talk about the benefits ofatumumab will do as well as the risks of using it.

Ofatumumab is to be given only by or under the direct supervision of your doctor.