Darunavir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide and Hydroxyprogesterone Caproate Injection (Makena)
Determining the interaction of Darunavir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide and Hydroxyprogesterone Caproate Injection (Makena) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Darunavir may increase the blood levels and effects of HYDROXYprogesterone. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with darunavir may increase the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. The mechanism is decreased clearance due to inhibition of CYP450 3A4 activity by darunavir.
MANAGEMENT: Caution is advised if darunavir must be used concurrently with medications that undergo metabolism by CYP450 3A4, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever darunavir is added to or withdrawn from therapy.
- "Product Information. Prezista (darunavir)." Ortho Biotech Inc, Bridgewater, NJ.
Generic Name: cobicistat / darunavir / emtricitabine / tenofovir alafenamide
Brand name: Symtuza
Synonyms: Cobicistat, darunavir, emtricitabine, and tenofovir
Generic Name: hydroxyprogesterone
Brand name: Makena, Makena Auto-Injector, Hylutin, Delta-Lutin, Duralutin, Hyprogesterone, Prodrox
Synonyms: Hydroxyprogesterone injection, Hydroxyprogesterone Caproate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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