Darunavir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide Fumarate and Mexiletine Hydrochloride

• Generic Name: cobicistat / darunavir / emtricitabine / tenofovir alafenamide
• Dosage Forms: n.a.
• Other Brand Names: Symtuza

Darunavir, cobicistat, emtricitabine, and tenofovir alafenamide fumarate is a four-drug combination of darunavir (DRV), an HIV-1 protease inhibitor, cobicistat (COBI), a CYP3A inhibitor, and emtricitabine (FTC) and tenofovir alafenamide (TAF), both HIV-1 NRTIs, and is indicated as a complete regimen for the treatment of HIV-1 infection in adults who have no prior antiretroviral treatment history or who are virologically suppressed (HIV-1 RNA less than 50 copies per mL) on a stable antiretroviral regimen for at least 6 months and have no known substitutions associated with resistance to darunavir or tenofovir.

• Generic Name: mexiletine
• Dosage Forms: n.a.
• Other Brand Names: Mexitil

Treatment of documented life-threatening ventricular arrhythmias (e.g., sustained ventricular tachycardia). Use for less severe arrhythmias is notrecommended.

Can reduce ventricular premature contractions (VPCs), paired VPCs, and nonsustained ventricular tachycardia and can suppress the recurrence of ventricular tachycardia and/or fibrillation in patients with ventricular tachycardia and/or fibrillation. Avoid treatment of asymptomatic VPCs.

Has been effective in some patients for the treatment of ventricular arrhythmias unresponsive to other antiarrhythmic agents.

Has been used with equivocal results in the management of painful diabetic neuropathy; pending further accumulation of data from well-designed studies, use only in patients who do not respond to or cannot tolerate more established therapies.