Darunavir Tablets and Edurant

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Darunavir may increase the blood levels and effects of rilpivirine. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with darunavir/ritonavir may increase the plasma concentrations of rilpivirine. The proposed mechanism is darunavir/ritonavir inhibition of the CYP450 3A4-mediated metabolism of rilpivirine. When rilpivirine 150 mg once a day and darunavir/ritonavir 800 mg/100 mg once a day were given together in 14 study subjects, mean rilpivirine peak plasma concentration (Cmax), systemic exposure (AUC) and trough plasma concentration (Cmin) increased by 79%, 130% and 178%, respectively. The clinical significance of these changes is unknown. The pharmacokinetics of darunavir were not significantly altered.

MANAGEMENT: No dosage adjustment is required for either darunavir/ritonavir or rilpivirine during concomitant use, but monitoring for potentially increased adverse effects of rilpivirine such as depression, hepatotoxicity, and prolongation of the QT interval may be advisable.

Darunavir Tablets

Generic Name: darunavir

Brand name: Prezista

Synonyms: Darunavir

What is Darunavir Tablets?

Edurant

Generic Name: rilpivirine

Brand name: Edurant

Synonyms: n.a.

What is Edurant?