Darunavir Tablets and Effexor XR (Venlafaxine Extended-Release Tablets)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Darunavir may increase the blood levels and effects of venlafaxine. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of venlafaxine and its metabolite, O-desmethylvenlafaxine (ODV). The possibility of prolonged and/or increased pharmacologic effects of venlafaxine should be considered. Although venlafaxine is primarily metabolized by CYP450 2D6, there is some evidence that CYP450 3A4 may play a minor role, thus any alteration in its activity levels could conceivably affect the metabolism of venlafaxine. The interaction may be of greater concern in patients who are CYP450 2D6-deficient, or so-called poor metabolizers of CYP450 2D6 (approximately 7% of Caucasians and less than 2% of Asians and individuals of African descent). In healthy volunteers, administration of single-dose venlafaxine with the potent CYP450 3A4 inhibitor ketoconazole (100 mg twice daily) increased venlafaxine systemic exposure (AUC) by 21% in extensive metabolizers and 70% (range -2% to 206%) in poor metabolizers of CYP450 2D6; increased AUC of ODV by 23% in extensive metabolizers and 33% (range -38% to 105%) in poor metabolizers; and increased combined AUC of venlafaxine and ODV by 23% in extensive metabolizers and 53% in poor metabolizers (range 4% to 134%). Venlafaxine and ODV peak plasma concentration (Cmax) also increased by 26% and 14%, respectively, in extensive metabolizers and 48% and 29%, respectively, in poor metabolizers.

MANAGEMENT: Caution is recommended when venlafaxine is used with CYP450 3A4 inhibitors.

Darunavir Tablets

Generic Name: darunavir

Brand name: Prezista

Synonyms: Darunavir

What is Darunavir Tablets?

Effexor XR (Venlafaxine Extended-Release Tablets)

Generic Name: venlafaxine

Brand name: Effexor XR, Effexor

Synonyms: Effexor XR

What is Effexor XR (Venlafaxine Extended-Release Tablets)?