Darunavir Tablets and Etravirine

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Coadministration with darunavir/ritonavir may decrease the plasma concentrations of etravirine. The mechanism of interaction has not been described but may involve ritonavir induction of CYP450 2C19 and 2C9, of which etravirine is a substrate. In 14 study subjects administered etravirine with darunavir/ritonavir (600 mg/100 mg) twice a day, etravirine peak plasma concentration (Cmax), systemic exposure (AUC) and trough plasma concentration (Cmin) decreased by 32%, 37% and 49%, respectively. Darunavir pharmacokinetics were not significantly affected. Because all subjects in Phase 3 trials of etravirine received darunavir/ritonavir as part of the background regimen and etravirine exposures from these trials were determined to be safe and effective, these drugs may be coadministered without any dosage adjustments.

Darunavir Tablets

Generic Name: darunavir

Brand name: Prezista

Synonyms: Darunavir

What is Darunavir Tablets?

Etravirine

Generic Name: etravirine

Brand name: Intelence

Synonyms: n.a.

What is Etravirine?