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Darunavir Tablets and Ezetimibe and Simvastatin Tablets

Determining the interaction of Darunavir Tablets and Ezetimibe and Simvastatin Tablets and the possibility of their joint administration.

Check result:

Darunavir Tablets <> Ezetimibe and Simvastatin Tablets

Relevance: 17.05.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using darunavir together with simvastatin is not recommended. Combining these medications may significantly increase the blood levels of simvastatin. This can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue. In some cases, rhabdomyolysis can cause kidney damage and even death. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications, or your doctor may prescribe alternative medications that do not interact. Let your doctor know immediately if you have unexplained muscle pain, tenderness, or weakness during treatment with simvastatin or similar medications, especially if these symptoms are accompanied by fever or dark colored urine. You should also seek immediate medical attention if you develop fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: Protease inhibitors (PIs) may significantly increase the plasma concentrations of certain HMG-CoA reductase inhibitors. The mechanism is PI inhibition of CYP450 3A4 metabolism. High levels of HMG-CoA reductase inhibitory activity in plasma are associated with an increased risk of musculoskeletal toxicity, including myopathy and rhabdomyolysis, which may be accompanied by acute renal failure secondary to myoglobinuria and may result in death.

MANAGEMENT: Simvastatin or lovastatin are considered contraindicated in patients treated with darunavir due to the potential for severe interaction. Other protease inhibitors should generally be avoided. Red yeast rice (which contains lovastatin) should also be avoided in patients treated with PIs. Fluvastatin and pravastatin are probably safer alternatives, since they are not metabolized by CYP450 3A4. All patients treated with HMG-CoA reductase inhibitors should be advised to promptly report any unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever. Therapy should be discontinued if creatine kinase is markedly elevated in the absence of strenuous exercise or if myopathy is otherwise suspected or diagnosed.

References

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Piliero PJ "Interaction between ritonavir and statins." Am J Med 112 (2002): 510-1
"Product Information. Lexiva (fosamprenavir)." GlaxoSmithKline, Research Triangle Park, NC.
"Product Information. Norvir (ritonavir)." Abbott Pharmaceutical, Abbott Park, IL.
"Product Information. Reyataz (atazanavir)." Bristol-Myers Squibb, Princeton, NJ.
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"Product Information. Prezista (darunavir)." Ortho Biotech Inc, Bridgewater, NJ.
"Product Information. Viracept (nelfinavir)." Agouron Pharma Inc, La Jolla, CA.

Darunavir Tablets

Generic Name: darunavir

Brand name: Prezista

Synonyms: Darunavir

What is Darunavir Tablets?

Ezetimibe and Simvastatin Tablets

Generic Name: ezetimibe / simvastatin

Brand name: Vytorin

Synonyms: Ezetimibe and simvastatin, Ezetimibe and Simvastatin

What is Ezetimibe and Simvastatin Tablets?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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