Drug search by name

Darunavir Tablets and Lopinavir and ritonavir

Determining the interaction of Darunavir Tablets and Lopinavir and ritonavir and the possibility of their joint administration.

Check result:

Darunavir Tablets <> Lopinavir and ritonavir

Relevance: 17.05.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using lopinavir together with darunavir. Using these medications together may decrease the effects of darunavir. Contact your doctor if your condition or infection worsens. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration with lopinavir/ritonavir may decrease the plasma concentrations of darunavir, even in the presence of low-dose ritonavir as a pharmacokinetic booster. The mechanism of interaction has not been described. In nine study subjects, administration of darunavir/ritonavir (300 mg/100 mg twice a day) with lopinavir/ritonavir (400 mg/100 mg twice a day) decreased the peak plasma concentration (Cmax), area under the concentration-time curve (AUC) and trough plasma concentration (Cmin) of darunavir by 39%, 53% and 65%, respectively, compared to administration without lopinavir/ritonavir. In contrast, lopinavir Cmax, AUC, and Cmin increased by 22%, 37%, and 72%, respectively, in the presence of darunavir/ritonavir.

MANAGEMENT: The appropriate dosage of darunavir when prescribed in combination with lopinavir/ritonavir has not been established. Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, the use of darunavir with lopinavir/ritonavir is not recommended, with or without an additional low-dose of ritonavir.

References

"Product Information. Prezista (darunavir)." Ortho Biotech Inc, Bridgewater, NJ.
Durant J, Clevenbergh P, Garraffo R, Halfon P, Icard S, DelGiudice P, Montagne N, Schapiro JM, Dellamonica P "Importance of protease inhibitor plasma levels in HIV-infected patients treated with genotypic-guided therapy: pharmacological data from the Viradapt Study." Aids 14 (2000): 1333-9

Darunavir Tablets

Generic Name: darunavir

Brand name: Prezista

Synonyms: Darunavir

What is Darunavir Tablets?

Lopinavir and ritonavir

Generic Name: lopinavir / ritonavir

Brand name: Kaletra

Synonyms: Lopinavir and Ritonavir

What is Lopinavir and ritonavir?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions