Darunavir Tablets and Lurasidone Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using lurasidone together with darunavir is not recommended. Combining these medications may significantly increase the blood levels of lurasidone. This may increase the risk of side effects such as Parkinson-like symptoms, abnormal muscle movements, seizures, high blood sugar, diabetes, high cholesterol, sex hormone irregularities, and heat-related disorders such as heat intolerance or heat stroke. You may also be more likely to experience side effects associated with low blood pressure such as dizziness, lightheadedness, headache, flushing, fainting, and heart palpitations. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Coadministration with potent inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of lurasidone and its active metabolite, both of which are primarily metabolized by the isoenzyme. In a pharmacokinetic study, administration of a single 10 mg dose of lurasidone with the potent CYP450 3A4 inhibitor ketoconazole (400 mg/day for 5 days) resulted in a 6.9-fold increase in lurasidone peak plasma concentration (Cmax) and a 9-fold increase in systemic exposure (AUC) compared to administration alone. The AUC of lurasidone's active metabolite increased by 6-fold.

MANAGEMENT: Concomitant use of lurasidone with potent CYP450 3A4 inhibitors is considered contraindicated.

Darunavir Tablets

Generic Name: darunavir

Brand name: Prezista

Synonyms: Darunavir

What is Darunavir Tablets?

Lurasidone Tablets

Generic Name: lurasidone

Brand name: Latuda

Synonyms: Lurasidone

What is Lurasidone Tablets?