Darunavir Tablets and Neoral

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Darunavir may increase the blood levels and effects of cycloSPORINE. You may need a dose adjustment if you have been taking cycloSPORINE and are starting treatment with darunavir. Contact your doctor if your condition changes or you experience increased side effects such as nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, headache, tremors, seizures, fever, sore throat, unusual bruising or bleeding, and increased or decreased urination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR CLOSELY: Coadministration with protease inhibitors (PIs), especially ritonavir, may significantly increase the blood concentrations of cyclosporine. The risk of nephro- and neurotoxicity associated with cyclosporine may be increased. The mechanism involves PI inhibition of CYP450 3A4, the isoenzyme responsible for the intestinal and hepatic metabolism of cyclosporine. Enhanced cyclosporine oral bioavailability due to PI inhibition of intestinal P-glycoprotein efflux transporter may also contribute. In an HIV+ renal transplant patient whose treatment regimen included cyclosporine (150 mg twice a day) prednisone, zidovudine and lamivudine, trough cyclosporine levels that had been stable in the 150 to 200 mcg/L range rose to 580 mcg/L three days after saquinavir therapy (1200 mg three times a day) was added. The patient reported fatigue, headache, and gastrointestinal discomfort. The dosage of both cyclosporine and saquinavir were subsequently reduced by 50%, which yielded a systemic exposure (AUC) of cyclosporine approximating that measured when cyclosporine was given at the original dose before saquinavir. However, saquinavir AUC was 11 times that reported in historical controls.

MANAGEMENT: Caution is advised if cyclosporine is used in combination with protease inhibitors. Cyclosporine blood levels and renal function should be checked frequently and the dosage adjusted accordingly, particularly following initiation or discontinuation of PI therapy in patients who are stabilized on their cyclosporine regimen. Patients should be advised to notify their physician if they experience possible signs of cyclosporine toxicity such as nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, headache, tremors, and convulsions. Patients treated with saquinavir should also be monitored for potential PI toxicity and the dosage adjusted accordingly.

Darunavir Tablets

Generic Name: darunavir

Brand name: Prezista

Synonyms: Darunavir

What is Darunavir Tablets?

Neoral

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Neoral (Capsules, Modified)

What is Neoral?