Darunavir Tablets and Nevirapine Suspension

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Nevirapine may reduce the blood levels of darunavir, which may make the medication less effective in treating your condition. Also, darunavir may increase the blood levels and effects of nevirapine. Contact your doctor if your condition changes or you experience increased side effects. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications that you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor

GENERALLY AVOID: Coadministration of darunavir-cobicistat with nevirapine may decrease the plasma concentrations of darunavir and/or cobicistat and increase the plasma concentrations of nevirapine. Reduced darunavir plasma levels may lead to diminished virologic response and possible resistance to darunavir. Increased nevirapine plasma concentrations may increase the risk of nevirapine-associated toxicity, including hepatotoxicity, fatal and non-fatal skin reactions (e.g., Stevens Johnson syndrome), and hypersensitivity reactions. The mechanism is nevirapine induction of the CYP450 3A4 isoenzyme and inhibition of CYP450 3A4 activity by darunavir and cobicistat. Pharmacokinetic data are not available for darunavir-cobicistat. However, when darunavir 400 mg-ritonavir 100 mg twice daily was used concomitantly with nevirapine 200 mg twice daily, there was increased systemic exposure (AUC) to nevirapine and darunavir of 27% and 24%, respectively. However, the trough plasma concentration (Cmin) of darunavir was unaffected. These changes are not considered to be clinically significant and do not warrant a dose adjustment to the standard recommended dose of darunavir-ritonavir.

MANAGEMENT: The concomitant use of darunavir-cobicistat with nevirapine is not recommended. As an alternative, darunavir boosted by low-dose ritonavir may be considered for use in combination with nevirapine.

Darunavir Tablets

Generic Name: darunavir

Brand name: Prezista

Synonyms: Darunavir

What is Darunavir Tablets?

Nevirapine Suspension

Generic Name: nevirapine

Brand name: Viramune, Viramune XR

Synonyms: Nevirapine

What is Nevirapine Suspension?