Drug search by name

Darunavir Tablets and Paroxetine Capsules

Determining the interaction of Darunavir Tablets and Paroxetine Capsules and the possibility of their joint administration.

Check result:

Darunavir Tablets <> Paroxetine Capsules

Relevance: 17.05.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using darunavir together with PARoxetine can decrease the effects of PARoxetine. Contact your doctor if your condition worsens. You may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with ritonavir- or cobicistat-boosted darunavir may decrease the plasma concentrations of paroxetine. The mechanism of interaction has not been described. In 16 study subjects, administration of paroxetine (20 mg once a day) in combination with darunavir/ritonavir (400 mg/100 mg twice a day) reduced the peak plasma concentration (Cmax), area under the concentration-time curve (AUC), and trough plasma concentration (Cmin) of paroxetine by approximately one-third compared to administration without darunavir/ritonavir. Paroxetine had no significant effect on the pharmacokinetics of darunavir.

MANAGEMENT: Patients treated concomitantly with ritonavir- or cobicistat-boosted darunavir may have diminished clinical response to paroxetine. Pharmacologic response to paroxetine should be monitored more closely whenever darunavir-ritonavir or darunavir-cobicistat is added to or withdrawn from therapy in patients stabilized on their existing antidepressant regimen, and the paroxetine dosage adjusted as necessary.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
"Product Information. Prezista (darunavir)." Ortho Biotech Inc, Bridgewater, NJ.
Cerner Multum, Inc. "Australian Product Information." O 0

Darunavir Tablets

Generic Name: darunavir

Brand name: Prezista

Synonyms: Darunavir

What is Darunavir Tablets?

Paroxetine Capsules

Generic Name: paroxetine

Brand name: Brisdelle, Paxil, Paxil CR, Pexeva

Synonyms: Paroxetine, PARoxetine

What is Paroxetine Capsules?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions