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Darunavir Tablets and Priftin

Determining the interaction of Darunavir Tablets and Priftin and the possibility of their joint administration.

Check result:

Darunavir Tablets <> Priftin

Relevance: 17.05.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using darunavir together with a rifapentine. Using these medications together can make darunavir less effective. Contact your doctor if your infection or condition worsens. You may need a dose adjustment or special tests to safely take both medications together. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration with rifapentine may decrease the plasma concentrations and antiretroviral effects of protease inhibitors. The mechanism is rifapentine induction of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of protease inhibitors. Rifapentine has been shown to substantially increase the clearance of indinavir when coadministered at their normally recommended dosages. Indinavir peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 55% and 70%, respectively, while rifapentine pharmacokinetics were unaffected. No data are available concerning the use of rifapentine with other protease inhibitors. However, the interaction is also expected to occur based on their similar metabolic profile to indinavir.

MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, the use of rifapentine should be avoided in patients receiving protease inhibitors.

References

"Product Information. Lexiva (fosamprenavir)." GlaxoSmithKline, Research Triangle Park, NC.
"Product Information. Priftin (rifapentine)." Hoechst Marion-Roussel Inc, Kansas City, MO.
Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
"Product Information. Invirase (saquinavir)." Roche Laboratories, Nutley, NJ.
"Product Information. Agenerase (amprenavir)." Glaxo Wellcome, Research Triangle Pk, NC.
Acosta EP, Henry K, Baken L, Page LM, Fletcher CV "Indinavir concentrations and antiviral effect." Pharmacotherapy 19 (1999): 708-12
"Product Information. Viracept (nelfinavir)." Agouron Pharma Inc, La Jolla, CA.
"Product Information. Crixivan (indinavir)." Merck & Co, Inc, West Point, PA.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Temple ME, Nahata MC "Rifapentine: its role in the treatment of tuberculosis." Ann Pharmacother 33 (1999): 1203-10
Durant J, Clevenbergh P, Garraffo R, Halfon P, Icard S, DelGiudice P, Montagne N, Schapiro JM, Dellamonica P "Importance of protease inhibitor plasma levels in HIV-infected patients treated with genotypic-guided therapy: pharmacological data from the Viradapt Study." Aids 14 (2000): 1333-9
"Product Information. Aptivus (tipranavir)." Boehringer-Ingelheim, Ridgefield, CT.
"Product Information. Fortovase (saquinavir)" Roche Laboratories, Nutley, NJ.
"Product Information. Prezista (darunavir)." Ortho Biotech Inc, Bridgewater, NJ.
Cerner Multum, Inc. "Australian Product Information." O 0
Sommadossi JP "HIV protease inhibitors: pharmacologic and metabolic distinctions." AIDS 13 (1999): s29-40
Barry M, Gibbons S, Back D, Mulcahy F "Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations." Clin Pharmacokinet 32 (1997): 194-209
"Product Information. Reyataz (atazanavir)." Bristol-Myers Squibb, Princeton, NJ.

Darunavir Tablets

Generic Name: darunavir

Brand name: Prezista

Synonyms: Darunavir

What is Darunavir Tablets?

Priftin

Generic Name: rifapentine

Brand name: Priftin

Synonyms: n.a.

What is Priftin?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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