Darunavir Tablets and Sustiva

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using efavirenz together with darunavir can decrease the effects of darunavir. Contact your doctor if your condition worsens. You may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with efavirenz may decrease the plasma concentrations of darunavir, even in the presence of cobicistat or low-dose ritonavir as a pharmacokinetic booster. Additionally, the plasma concentration of cobicistat may be reduced. Reduced darunavir plasma levels may lead to diminished virologic response and possible resistance to darunavir. The mechanism is efavirenz induction of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of darunavir and cobicistat. In 12 study subjects, administration of darunavir/ritonavir (300 mg/100 mg twice a day) with efavirenz (600 mg once a day) decreased the peak plasma concentration (Cmax), area under the concentration-time curve (AUC) and trough plasma concentration (Cmin) of darunavir by 15%, 13% and 31%, respectively, compared to administration without efavirenz. In contrast, efavirenz Cmax, AUC, and Cmin increased by 15%, 21%, and 17%, respectively, in the presence of darunavir/ritonavir. The clinical significance of these changes are unknown. Data are not available for darunavir-cobicistat.

MANAGEMENT: Caution is advised if darunavir-ritonavir is coadministered with efavirenz. Antiretroviral response should be monitored closely and darunavir-ritonavir dose adjusted if necessary. Some authorities recommend a dose adjustment of darunavir 600 mg-ritonavir 100 mg twice daily. Concomitant use of darunavir-cobicistat with efavirenz is not recommended.

Darunavir Tablets

Generic Name: darunavir

Brand name: Prezista

Synonyms: Darunavir

What is Darunavir Tablets?

Sustiva

Generic Name: efavirenz

Brand name: Sustiva

Synonyms: n.a.

What is Sustiva?