Darunavir Tablets and Tipranavir

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ask your doctor before using darunavir together with tipranavir. Using these medications together may cause darunavir to be less effective. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with tipranavir plus low-dose ritonavir may significantly decrease the plasma concentrations of other protease inhibitors. The mechanism of interaction has not been described. Data are available for amprenavir, atazanavir, lopinavir, and saquinavir. In 16 HIV-positive subjects, administration of amprenavir (600 mg plus ritonavir 100 mg) in combination with tipranavir/ritonavir (500 mg/200 mg) twice a day for 14 days decreased the mean steady-state peak plasma concentration (Cmax), systemic exposure (AUC) and trough plasma concentration (Cmin) of amprenavir by 39%, 44% and 55%, respectively, compared to administration without tipranavir/ritonavir. In 21 HIV-positive subjects, mean steady-state Cmax, AUC and Cmin of lopinavir (400 mg plus ritonavir 100 mg) decreased by 47%, 55% and 70%, respectively, while those of saquinavir (600 mg plus ritonavir 100 mg) decreased by 70%, 76% and 82%, respectively, during coadministration with tipranavir/ritonavir twice a day for 14 days. Likewise, mean steady-state Cmax, AUC and Cmin of atazanavir decreased by 57%, 68% and 81%, respectively, when atazanavir (300 mg plus ritonavir 100 mg once a day) was coadministered with tipranavir/ritonavir (500 mg/100 mg twice a day) for nine days in 13 subjects with unspecified HIV status. Atazanavir plus ritonavir increased tipranavir AUC by 20% and Cmin by 75%.

MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, use of other protease inhibitors in combination with tipranavir/ritonavir is not recommended.

Darunavir Tablets

Generic Name: darunavir

Brand name: Prezista

Synonyms: Darunavir

What is Darunavir Tablets?

Tipranavir

Generic Name: tipranavir

Brand name: Aptivus

Synonyms: n.a.

What is Tipranavir?