Darunavir Tablets and Triumeq

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Coadministration with darunavir/ritonavir may modestly decrease the plasma concentrations of dolutegravir. The exact mechanism of interaction has not been established, but may partially involve ritonavir induction of dolutegravir metabolism via UGT1A1. In 15 study subjects, administration of dolutegravir 30 mg once daily with darunavir/ritonavir 600 mg/100 mg twice daily decreased dolutegravir peak plasma concentration (Cmax), systemic exposure (AUC) and trough plasma concentration (Cmin; 24 hours postdose) by 11%, 22% and 38%, respectively, compared to administration without darunavir/ritonavir. These changes are not considered clinically significant. Using cross-study comparisons to historical pharmacokinetic data, dolutegravir did not appear to affect the pharmacokinetics of darunavir or ritonavir.

Darunavir Tablets

Generic Name: darunavir

Brand name: Prezista

Synonyms: Darunavir

What is Darunavir Tablets?

Triumeq

Generic Name: abacavir / dolutegravir / lamivudine

Brand name: Triumeq

Synonyms: n.a.

What is Triumeq?