Darvon and Prochlorperazine

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using prochlorperazine together with propoxyphene can add to the side effects of either medication. This may be more likely to occur in older adults or those with a debilitating condition. Talk with your doctor before using these medications together. Call the doctor if you have side effects such as tiredness, excessive sedation, dizziness, feel faint, seizures, and/or irregular heartbeat. You should avoid activities requiring mental alertness until they know how these medications will affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR CLOSELY: Concomitant use of propoxyphene and phenothiazines may result in additive central nervous system (CNS) depressant effects. Misuse of propoxyphene, either alone or in combination with other CNS depressants, has been a major cause of drug-related deaths, particularly in patients with a history of emotional disturbances, suicidal ideation, or alcohol and drug abuse. In a large Canadian study, propoxyphene use was also associated with a 60% increased risk of hip fracture in the elderly, and the risk was further increased by concomitant use of psychotropic agents including neuroleptics, presumably due to additive psychomotor impairment. Therefore, these drugs may constitute a dangerous combination in certain susceptible populations. Pharmacokinetically, propoxyphene may increase the plasma concentrations of phenothiazines by inhibiting their metabolism via CYP450 2D6. In addition to enhanced CNS depression, the possibility of increased adverse effects of phenothiazines such as tardive dyskinesia, hypotension, and prolongation of the QT interval should be considered. Many of these agents alone can and have produced these effects.

MANAGEMENT: Caution is advised if propoxyphene is prescribed with phenothiazines, particularly in the elderly and in patients with a history of emotional disturbances, suicidal ideation, or alcohol and drug abuse. Dosage reductions may be required. Patients should be warned not to exceed recommended dosages, to avoid alcohol, and to notify their physician if they experience symptoms of toxicity such as lethargy, excessive sedation, dizziness, syncope, seizures, and/or irregular heartbeat. In addition, they should avoid activities requiring mental alertness until they know how these agents affect them.

Darvon

Generic Name: propoxyphene

Brand name: Darvon, Darvon-N, PP-Cap

Synonyms: n.a.

What is Darvon?

Prochlorperazine

Generic Name: prochlorperazine

Brand name: Compazine, Compro

Synonyms: n.a.

What is Prochlorperazine?