Dasatinib and Os-Cal 500+D

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Taking the dasatinib and calcium carbonate doses too close together may interfere with the absorption of dasatinib and reduce its effectiveness. To prevent or minimize the interaction, dasatinib and calcium carbonate dosing should be separated by at least two hours. Contact your doctor if your condition worsens. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSING INTERVAL: Nonclinical data indicate that the solubility of dasatinib is pH-dependent. Therefore, coadministration with antacids or agents with acid-neutralizing effects may reduce the oral bioavailability of dasatinib. In a pharmacokinetic study of 24 healthy subjects, administration of a 50 mg dose of dasatinib with 30 mL of aluminum hydroxide/magnesium hydroxide was associated with a 55% reduction in systemic exposure (AUC) and a 58% reduction in peak plasma concentration (Cmax) of dasatinib. However, when the same dose of aluminum hydroxide/magnesium hydroxide was administered two hours prior to the dasatinib dose, there was no significant change in dasatinib systemic exposure (AUC), and the dasatinib Cmax was increased 26%.

MANAGEMENT: Patients treated with dasatinib should avoid taking antacids or oral medications that contain antacids (e.g., didanosine buffered tablets or paediatric oral solution) for at least two hours before and two hours after administration of dasatinib.

Dasatinib

Generic Name: dasatinib

Brand name: Sprycel

Synonyms: n.a.

What is Dasatinib?

Os-Cal 500+D

Generic Name: calcium / vitamin d

Brand name: Calcitrate, Caltrate 600+D, Os-Cal 500+D, Calcitrate with D, Caltrate 600+D Soft Chews, Citracal + D, Os-Cal Extra D3, Oystercal-D, UpCal D, Os-Cal 250 with D, Oysco D, Dical-D, Calcet, Oyster Shell Calcium with Vitamin D, O-Cal-D, Oyster-D, Oyst-Cal-D, Caltro with Vitamin D, Oysco 500 with D, Oysco D with Calcium, Os-Cal with D, Caltrate 600 with D, Calcarb with D, Posture-D H/P, Dical Captabs, Dicalphos plus D, Os-Cal 500 with D, Caltrate 600 with D Plus Soy, Caltrate Colon Health, Calvite P & D, Sedecal D, Chewable Calcium with Vitamin D, Osteocit D Plus, Os-Cal 500 + D, Citracal Petites, Citracal Creamy Bites, Citracal 250 mg + D, Calcio Del Mar, Citrus Calcium with Vitamin D, Calcium 600+D, Risacal-D, Liquid Calcium with Vitamin D, Citracal Maximum + D, Citracal Calcium + D Slow Release 1200, Citracal Calcium Gummies, Caltrate Gummy Bites, Super Calcium 600 + D3 400, Os-Cal Calcium+D3, Caltrate 600 + D, Citracal Regular, Calcet Petites, Calcium 500+D, D3 with Calcium, Os-Cal 500+Extra D Chewable

Synonyms: n.a.

What is Os-Cal 500+D?