DayQuil Severe Cold & Flu and I-123 MIBG
Determining the interaction of DayQuil Severe Cold & Flu and I-123 MIBG and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Phenylephrine may interfere with imaging studies done with iobenguane I-123. Let your doctor know you are receiving or have recently received phenylephrine if you are scheduled for an imaging procedure to detect pheochromocytoma or neuroblastoma (tumors in the nervous system). You may need to stop using phenylephrine for a certain amount of time before having the procedure. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with drugs that block norepinephrine uptake or deplete norepinephrine stores may decrease iobenguane I-123 uptake in neuroendocrine tumors and lead to false-negative imaging results. Since iobenguane I-123 is subject to the same uptake and accumulation pathways as norepinephrine, drugs that alter norepinephrine disposition in adrenergic nerve terminals and presynaptic storage vesicles will likewise affect iobenguane. These drugs include antihypertensive agents that deplete norepinephrine stores or inhibit reuptake (e.g., guanethidine, reserpine, labetalol); antidepressants that inhibit norepinephrine transporter function (e.g., tricyclic antidepressants, selective serotonin reuptake inhibitors); sympathomimetic amines (e.g., phenylephrine, phenylpropanolamine, pseudoephedrine, ephedrine); central nervous stimulants (e.g., amphetamines); phenothiazines; and cocaine. Clinical studies have not determined which specific drugs may cause false-negative imaging results and whether all drugs in a specific pharmacologic class have the same potential to produce negative imaging results. Increasing the dose of iobenguane I-123 will not overcome any potential effect of these drugs.
MANAGEMENT: When medically feasible, any drug that blocks norepinephrine uptake or deplete norepinephrine stores should be discontinued for at least five biological half-lives before iobenguane I-123 administration. Patients should be monitored for the occurrence of clinically significant withdrawal symptoms, especially patients with elevated levels of circulating catecholamines and their metabolites.
- "Product Information. AdreView (iobenguane I-123)." GE Healthcare, Princeton, NJ.
Generic Name: acetaminophen / dextromethorphan / guaifenesin / phenylephrine
Brand name: DayQuil Severe Cold & Flu, Delsym Cough Plus Cold Day Time, Mucinex Children's Cold, Cough & Sore Throat, Mucinex Fast-Max Severe Cold, Sudafed PE Cold & Cough, Tylenol Cold & Flu Severe, Tylenol Cold Multi-Symptom Severe, Mucinex Sinus-Max, Sudafed PE Cold/Cough, Tylenol Cold Head Congestion, Tylenol Cold Multi Symptom, Tylenol Cold/Flu Severe, Vicks DayQuil Severe Cold/Flu
Synonyms: n.a.
Generic Name: iobenguane I 123
Brand name: AdreView
Synonyms: Iobenguane I-123
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- DayQuil Severe Cold & Flu-I-131 Mini
- DayQuil Severe Cold & Flu-I-Prin
- DayQuil Severe Cold & Flu-I3odine Max
- DayQuil Severe Cold & Flu-Ibandronate
- DayQuil Severe Cold & Flu-Ibandronate Injection
- DayQuil Severe Cold & Flu-Ibandronate Intravenous
- I-123 MIBG-Daysee
- I-123 MIBG-Daysee extended-cycle
- I-123 MIBG-Daytime
- I-123 MIBG-Daytime Cold
- I-123 MIBG-Daytrana
- I-123 MIBG-Daytrana Patch