De-Sone LA injection and Midazolam Hydrochloride
Determining the interaction of De-Sone LA injection and Midazolam Hydrochloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Certain corticosteroids may decrease the plasma concentration of some benzodiazepines. Limited data are available for midazolam and triazolam. The mechanism is related to induction of hepatic cytochrome P450 enzymes responsible for benzodiazepine metabolism. The clinical significance may depend on the dosage and duration of corticosteroid therapy and be of greater importance with oral administration of benzodiazepines.
- Villikka K, Kivisto KT, Neuvonen PJ "The effect of dexamethasone on the pharmacokinetics of triazolam." Pharmacol Toxicol 83 (1998): 135-8
- Nakajima M, Suzuki T, Sasaki T, Yokoi T, Hosoyamada A, Yamamoto T, Kuroiwa Y "Effects of chronic administration of glucocorticoid on midazolam pharmacokinetics in humans." Ther Drug Monit 21 (1999): 507-13
Generic Name: dexamethasone
Brand name: De-Sone LA, Dexacen-4, Dexasone, Dexasone LA, Solurex, Solurex LA, Baycadron, Dexamethasone Intensol, DexPak 10 Day Taperpak, DexPak 13 DayTaperpak, DexPak 6 DayTaperpak, Decadron, DexPak, TaperDex, Zema-Pak, ZoDex, Zonacort
Synonyms: De-Sone LA (injection)
Generic Name: midazolam
Brand name: Versed, Nayzilam
Synonyms: Midazolam
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- De-Sone LA injection-Midazolam injection
- De-Sone LA injection-Midazolam Injection Hospira
- De-Sone LA injection-Midazolam nasal
- De-Sone LA injection-Midazolam Nasal Spray
- De-Sone LA injection-Midazolam Syrup
- De-Sone LA injection-Midodrine
- Midazolam Hydrochloride-Deblitane
- Midazolam Hydrochloride-Decadron
- Midazolam Hydrochloride-Decadron Elixir
- Midazolam Hydrochloride-Decara
- Midazolam Hydrochloride-Decavac
- Midazolam Hydrochloride-Decavac (Td) Td