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Decadron and Methergine

Determining the interaction of Decadron and Methergine and the possibility of their joint administration.

Check result:

Decadron <> Methergine

Relevance: 08.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Dexamethasone may reduce the blood levels and effects of methylergonovine. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of ergot alkaloids, which are substrates of the isoenzyme.

MANAGEMENT: The potential for diminished therapeutic effects of ergot alkaloids should be considered when used in combination with CYP450 3A4 inducers.

References

"Product Information. Methergine (methylergonovine)." Novartis Pharmaceuticals, East Hanover, NJ.

Decadron

Generic Name: dexamethasone

Brand name: Baycadron, Dexamethasone Intensol, DexPak 10 Day Taperpak, DexPak 13 DayTaperpak, DexPak 6 DayTaperpak, De-Sone LA, Dexacen-4, Dexasone, Dexasone LA, Solurex, Solurex LA, Decadron, DexPak, TaperDex, Zema-Pak, ZoDex, Zonacort

Synonyms: Decadron (Oral)

What is Decadron?

Methergine

Generic Name: methylergonovine

Brand name: Methergine

Synonyms: Methergine (oral and injection)

What is Methergine?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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