Decadron and Pradaxa

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Dexamethasone may reduce the blood levels of dabigatran, which may make the medication less effective in preventing blood clots. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with inducers of P-glycoprotein (P-gp) may reduce the bioavailability of dabigatran following oral administration of dabigatran etexilate, which is a substrate of the efflux transporter. When a single dose of dabigatran etexilate was administered following pretreatment with the potent P-gp inducer rifampin (600 mg once daily for 7 days), dabigatran peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by approximately two-thirds compared to the reference treatment. Dabigatran exposure was close to normal seven days after cessation of rifampin. No data are available for other, less potent P-glycoprotein inducers.

MANAGEMENT: Concomitant use of dabigatran with P-gp inducers should generally be avoided. Otherwise, caution is advised. Pharmacologic response to dabigatran should be monitored more closely whenever a P-gp inducer is added to or withdrawn from therapy, and the dabigatran dosage adjusted as necessary.

Decadron

Generic Name: dexamethasone

Brand name: Baycadron, Dexamethasone Intensol, DexPak 10 Day Taperpak, DexPak 13 DayTaperpak, DexPak 6 DayTaperpak, De-Sone LA, Dexacen-4, Dexasone, Dexasone LA, Solurex, Solurex LA, Decadron, DexPak, TaperDex, Zema-Pak, ZoDex, Zonacort

Synonyms: Decadron (Oral)

What is Decadron?

Pradaxa

Generic Name: dabigatran

Brand name: Pradaxa

Synonyms: n.a.

What is Pradaxa?