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Decorel Forte Plus Cold/Cough and Fenoldopam Intravenous

Determining the interaction of Decorel Forte Plus Cold/Cough and Fenoldopam Intravenous and the possibility of their joint administration.

Check result:

Decorel Forte Plus Cold/Cough <> Fenoldopam Intravenous

Relevance: 10.10.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

The use of acetaminophen has been associated with a 32% increase in orally-administered fenoldopam plasma concentrations and a 50% increase in the area under the plasma concentration versus time curve for fenoldopam. These data suggest that acetaminophen may significantly increase exposure to fenoldopam and increase its hypotensive effect. Data are available for orally administered fenoldopam only. Since fenoldopam is available as an intravenously administered drug for emergent hypertension, its dose can be rapidly titrated in cases of hypotension.

References

Ziemniak JA, Allison N, Boppana VK, Dubb J, Stote R "The effect of acetaminophen on the disposition of fenoldopam: competition for sulfation." Clin Pharmacol Ther 41 (1987): 275-81
Brogden RN, Markham A "Fenoldopam: a review of its pharmacodynamic and pharmacokinetic properties and intravenous clinical potential in the management of hypertensive urgencies and emergencies." Drugs 54 (1997): 634-50

Decorel Forte Plus Cold/Cough

Generic Name: acetaminophen / dextromethorphan / guaifenesin / phenylephrine

Brand name: Decorel Forte Plus Cold/Cough, Mucinex Fast-Max, Mucinex Fast-Max Cold and Flu, Mucinex Fast-Max Congestion and Cold, Mucinex Fast-Max Severe Cold, Tylenol Cold Multi-Symptom Severe Daytime, Tylenol Cold Head Congestion Severe, Non-Pseudo Cold Relief, Phenflu DM, Sudafed PE Cold & Cough, Cold & Cough PE, Cold Head Congestion Severe Daytime, Cold Multi-Symptom Severe Daytime Cool Ice, Tylenol Cold & Flu Severe, Mucinex Children's Multi-Symptom Cold & Fever, Mucinex Fast-Max Cold, Flu & Sore Throat, Mucinex Fast-Max Severe Congestion & Cold, Cough & Sore Throat, DayQuil Severe Cold & Flu, Adult Cold, Cold & Flu Severe, Mucinex Sinus-Max Severe Congestion Relief, Delsym Cough + Cold Daytime, Severe Day Time Cold & Flu, Mucinex Fast-Max Cold & Flu, Mucinex Sinus-Max Pressure, Pain & Cough

Synonyms: n.a.

What is Decorel Forte Plus Cold/Cough?

Fenoldopam Intravenous

Generic Name: fenoldopam

Brand name: Corlopam

Synonyms: Fenoldopam

What is Fenoldopam Intravenous?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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