Decorel Forte Plus Cold/Cough and Vyndaqel

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.MONITOR: Based on in vitro data, coadministration with tafamidis may increase the plasma concentrations and the risk of toxicity of drugs that are substrates of the transport protein breast cancer resistance protein (BCRP) (e.g., methotrexate, rosuvastatin, imatinib), uridine diphosphate glucuronosyltransferase (UGT) 1A1 (e.g., bictegravir, irinotecan, raltegravir), and/or uptake transporters OAT1 and OAT3 (organic anion transporters) (e.g., bumetanide, furosemide, lamivudine, methotrexate, oseltamivir, tenofovir, ganciclovir, adefovir, cidofovir, zidovudine, zalcitabine) at clinically relevant concentrations. The proposed mechanism is decreased clearance due to tafamidis-mediated inhibition of the corresponding transport protein. MANAGEMENT: Caution is advised if tafamidis is used concomitantly with drugs that are substrates of these transport proteins, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring should be considered whenever tafamidis is added to or withdrawn from therapy with these drugs. Patients should be monitored for the development of adverse effects. References Agencia Española de Medicamentos y Productos Sanitarios Healthcare "Centro de información online de medicamentos de la AEMPS - CIMA. Available from: URL: https://cima.aemps.es/cima/publico/home.html." ([2018]): "Product Information. Vyndaqel (tafamidis)." Pfizer U.S. Pharmaceuticals Group, New York, NY. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

MONITOR: Based on in vitro data, coadministration with tafamidis may increase the plasma concentrations and the risk of toxicity of drugs that are substrates of the transport protein breast cancer resistance protein (BCRP) (e.g., methotrexate, rosuvastatin, imatinib), uridine diphosphate glucuronosyltransferase (UGT) 1A1 (e.g., bictegravir, irinotecan, raltegravir), and/or uptake transporters OAT1 and OAT3 (organic anion transporters) (e.g., bumetanide, furosemide, lamivudine, methotrexate, oseltamivir, tenofovir, ganciclovir, adefovir, cidofovir, zidovudine, zalcitabine) at clinically relevant concentrations. The proposed mechanism is decreased clearance due to tafamidis-mediated inhibition of the corresponding transport protein.

MANAGEMENT: Caution is advised if tafamidis is used concomitantly with drugs that are substrates of these transport proteins, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring should be considered whenever tafamidis is added to or withdrawn from therapy with these drugs. Patients should be monitored for the development of adverse effects.

Decorel Forte Plus Cold/Cough

Generic Name: acetaminophen / dextromethorphan / guaifenesin / phenylephrine

Brand name: Decorel Forte Plus Cold/Cough, Mucinex Fast-Max, Mucinex Fast-Max Cold and Flu, Mucinex Fast-Max Congestion and Cold, Mucinex Fast-Max Severe Cold, Tylenol Cold Multi-Symptom Severe Daytime, Tylenol Cold Head Congestion Severe, Non-Pseudo Cold Relief, Phenflu DM, Sudafed PE Cold & Cough, Cold & Cough PE, Cold Head Congestion Severe Daytime, Cold Multi-Symptom Severe Daytime Cool Ice, Tylenol Cold & Flu Severe, Mucinex Children's Multi-Symptom Cold & Fever, Mucinex Fast-Max Cold, Flu & Sore Throat, Mucinex Fast-Max Severe Congestion & Cold, Cough & Sore Throat, DayQuil Severe Cold & Flu, Adult Cold, Cold & Flu Severe, Mucinex Sinus-Max Severe Congestion Relief, Delsym Cough + Cold Daytime, Severe Day Time Cold & Flu, Mucinex Fast-Max Cold & Flu, Mucinex Sinus-Max Pressure, Pain & Cough

Synonyms: n.a.

What is Decorel Forte Plus Cold/Cough?

Vyndaqel

Generic Name: tafamidis

Brand name: Vyndamax, Vyndaqel

Synonyms: n.a.

What is Vyndaqel?