Deferasirox and Uniphyl
Determining the interaction of Deferasirox and Uniphyl and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Deferasirox may significantly increase the blood levels of theophylline, which may lead to potentially serious and life-threatening side effects. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you develop nausea, vomiting, diarrhea, loss of appetite, headache, tremor, confusion, restlessness, insomnia, seizures, heart palpitations, and/or irregular heartbeat, as these may be signs and symptoms of excessive theophylline levels. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with deferasirox may significantly increase the plasma concentrations of theophylline. The proposed mechanism is deferasirox inhibition of CYP450 1A2, the isoenzyme primarily responsible for the metabolic clearance of theophylline. In a study of healthy volunteers, administration of a single 120 mg dose of theophylline in combination with deferasirox (repeated dosing of 30 mg/kg/day) resulted in an approximate doubling of theophylline systemic exposure (AUC) and elimination half-life. The single-dose peak plasma concentration (Cmax) was not affected, but an increase in theophylline Cmax is expected to occur with chronic dosing.
MANAGEMENT: Given the potential risk for theophylline toxicity, concomitant use with deferasirox should generally be avoided. Dosage adjustment for theophylline may be needed if coadministration with deferasirox is required. Close monitoring of serum theophylline levels is recommended, particularly following the addition, discontinuation, or change of dosage of deferasirox. Patients should be advised to notify their physician if they experience signs of theophylline toxicity such as nausea, vomiting, diarrhea, headache, restlessness, insomnia, seizures, palpitations, and cardiac arrhythmia.
- "Product Information. Exjade (deferasirox)." Novartis Pharmaceuticals, East Hanover, NJ.
Generic Name: deferasirox
Brand name: Exjade, Jadenu, Jadenu Sprinkle
Synonyms: n.a.
Generic Name: theophylline
Brand name: Elixophyllin, Theo-24, Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Theochron, Slo-Phyllin 125, Theoclear LA-130, Aerolate JR, Theolair-SR, Theoclear LA-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCap
Synonyms: Uniphyl (Oral)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- Deferasirox-Unisom with Pain Relief
- Deferasirox-Unithroid
- Uniphyl-Deferasirox Sprinkle Granules
- Uniphyl-Deferasirox Tablets
- Uniphyl-Deferasirox Tablets For Oral Suspension
- Uniphyl-Deferiprone
- Uniphyl-Deferiprone Oral Solution
- Uniphyl-Deferiprone Tablets