Deferasirox Tablets For Oral Suspension and Doxorubicin liposome Intravenous
Determining the interaction of Deferasirox Tablets For Oral Suspension and Doxorubicin liposome Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Deferasirox may reduce the blood levels of DOXOrubicin liposomal in some patients, which may make the medication less effective in treating your cancer. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of doxorubicin, which is primarily metabolized by the isoenzyme. One group of investigators reported a nearly 60% increase in the plasma clearance of doxorubicin in patients receiving barbiturates compared to those not receiving barbiturates. Reduced therapeutic effects of doxorubicin may occur.
MANAGEMENT: Concomitant use of doxorubicin with CYP450 3A4 inducers should generally be avoided, particularly potent ones like carbamazepine, enzalutamide, lumacaftor, mitotane, phenobarbital, phenytoin, primidone (partially metabolized to phenobarbital), rifamycins, and St. John's wort. Close monitoring for potentially reduced efficacy of doxorubicin is recommended if coadministration is required.
- Riggs CE Jr, Engel S, Wesley M, Wiernik PH, Bachur NR "Doxorubicin pharmacokinetics: prochlorperazine and barbiturate effects." Clin Pharmacol Ther 31 (1982): 263
- "Product Information. Adriamycin PFS (doxorubicin)." Pharmacia and Upjohn, Kalamazoo, MI.
- "Product Information. Doxil (doxorubicin liposomal)." Sequis Pharmaceuticals Inc, Menlo Park, CA.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: deferasirox
Brand name: Exjade, Jadenu, Jadenu Sprinkle
Synonyms: Deferasirox
Generic Name: doxorubicin liposomal
Brand name: Doxil, Lipodox, Lipodox 50
Synonyms: Doxorubicin liposomal, DOXOrubicin (Liposomal)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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